From 1890 to 1925, the school continued to prosper under the guidance of Mr. S.B. Wilson, M.A. and his successors, nameley Mr. F.G. Bowers, Rev. J.B. Longden, Rev. W.J.P. White, Rev. Arthur Robinson, Rev. Leonard Edge and Rev. Leonard Simpson. Then, in 1925, the Rev. R.P. Dyer, M.B.E., M.A., took up the appointment as Headmaster and it is he who made Queen’s College the school it is today. He began to groom students for the day they could move into positions of leadership and it was Rev. Dyer who urged Charles Sweeting into education, predicting, in 1957, that he would one day be the first Bahamian Principal of the school. Rev. Dyer remained as Headmaster until his retirement in 1959. Upon his death in 1961, he was buried in the churchyard of Ebenezer Methodist Church, Shirley Street.
The Rev. Dyer was succeeded by Rev. Geoffrey Litherland (1959 – 1964), Rev. Neville Stewart (1964 – 1971) and Mr. Hayden Middleton (1971 – 1979), each of whom made outstanding contributions to the development of Queen’s College during their tenures.
The first Bahamian administrator of Queen’s College, Mrs. Yvonne Noronha, was appointed Vice Principal of the College and Headmistress of the Primary School in 1978. This was closely followed by the appointment of Rev. Charles Sweeting in 1979, the first old scholar and first Bahamian to be appointed Principal. Reverend Sweeting served as Principal until 1993. Vice Principal, Mr. Philip Cash was appointed Principal in 1993 and served the school until his death in June 1997. In November 1997, Miss Andrea Gibson, the first female and third former scholar to serve the school, was appointed Principal. Mrs. Virginia Minnis was appointed Head of the Early Learning Centre in September 1999 and is the first Bahamian to serve in this post.